Nike Performance AIR ZOOM CAGE 3 HC Outdoor tennis shoes white/universal red/light cream/metallic gold dXt5U1

SKU-76302421447
Nike Performance AIR ZOOM CAGE 3 HC - Outdoor tennis shoes - white/universal red/light cream/metallic gold dXt5U1
Nike Performance AIR ZOOM CAGE 3 HC - Outdoor tennis shoes - white/universal red/light cream/metallic gold
Hallmark
View your shopping cart, you

Your cart: 0 item s

Subtotal: 0 item s $0.00
Sign Send $0.00
Shipping $0.00
Estimated tax $0.00
Total $0.00
Crown Rewards 000 points
Shop Birthday
PAUL ANDREW Rhea Suede Slingback Flats bfxZJercb
Shop Just Because Collection
Shop Friendship Day Cards
Shop Sign Send
Shop Just Because Collection
Shop Wonderfolds
Shop Star Wars™
Nike Performance WMNS AIR ZOOM VOMERO 13 Neutral running shoes cool grey/pure platinum/wolf grey/white sFCjpeiG
Shop Friendship Day
Shop Personalized Ornaments
Shop Birthday Gift Wrap
Shop Summer Décor
Bottega Veneta Dark navy suede voortrekking boot uvrlByxs
Shop Willow Tree®
Enroll in KOC now
Learn more about Ornament Premiere
Enroll in KOC now
Learn more about Ornament Premiere
Shop Peanuts®
Shop Just Because Collection
Shop Marvel
Shop Ken Sheldon
Wedding Wishes: What to Write
Play with Your Food: Baby
Nike Performance AIR ZOOM STRUCTURE 21 Stabilty running shoes black/white/wolf grey/cool grey/dark grey 3wjGrs

The observation that hypoxia-induced K ATP channel activation is beneficial in mammals raises the possibility that a similar response in aquatic ectotherms could promote tolerance of environmental hypoxia. SarcK ATP channel currents have been recorded in isolated myocytes from the hearts of several teleost species ( Ganim et al., 1998 ; Paajanen and Vornanen, 2002 ), and there is evidence for the existence of cardiac mitoK ATP channels in fish ( MacCormack and Driedzic, 2002 ). In addition, nitric oxide synthase (NOS) has been localized in the hearts of goldfish ( Bruning et al., 1996 ), and NO has been shown to play a critical role, via cGMP, in regulating the heart and peripheral vasculature in a variety of teleost species ( Imbrogno et al., 2003 ; Jennings et al., 2004 ; Dsquared2Contrast panel trainers QKcrd0DO
). In goldfish, NO synthesized in cardiac myocytes plays a role in sarcK ATP channel activation during moderate hypoxia ( Cameron et al., 2003 ). Although it has been proposed that hypoxia-induced K ATP channel activation, whether in the heart or in the brain, contributes to the enhanced tolerance of environmental oxygen depletion exhibited by many ectothermic vertebrates ( Cameron and Baghdady, 1994 ; Pek-Scott and Lutz, 1998 ), this possibility has not been directly tested in fish.

The purpose of the present study, then, was to determine whether sarcK ATP or mitoK ATP channel activation exerts a cardioprotective effect during hypoxia in goldfish. This species is highly tolerant of depleted environmental oxygen; indeed, the congeneric crucian carp Carassius carassius retains normal cardiac function for 5 days of complete anoxia ( Stecyk et al., 2004 ). A cellular model of environmental hypoxia was used to examine the effects of altered channel activity on isolated myocytes. Our hypothesis was that the NO- and cGMP-dependent activation of cardiac K ATP channels would promote survival of isolated cells, thereby contributing to a suite of mechanisms that dramatically enhance tolerance of hypoxia in these fish. Preliminary results of this work have appeared in abstract form ( Zhu et al., 2004 ).

Skip to Previous Section Skip to Next Section

Goldfish Carassius auratus L. were obtained from local suppliers and acclimated at 21°C in filtered, aerated 200 liter aquaria under a 12 h:12 h light:dark cycle. On the day of an experiment, goldfish of either sex were anesthetized by immersion in a solution of MS-222 (tricaine methanesulfonate, 0.2 g l –1 ; pH 7.6). The heart was rapidly excised and prepared for standard intracellular recording using the intact ventricle, or for enzymatic dispersion of individual myocytes.

Table 1. Sample size and assurance probabilities for observing criteria (i), (ii), and (iii) given = 0.025, = 0.1, (Δ , Δ ) = (3,0.45), ( , ) = (6,1), ( , ) = (0.5, 0.5), and = 0.1.

https://doi.org/10.1371/journal.pone.0180405.t001

Table 2. Sample size and assurance probabilities for observing criteria (i), (ii), and (iii) given = 0.025, = 0.1, (Δ , Δ ) = (3,0.45), ( , ) = (6,1), ( , ) = (0.5, 0.5), and = 0.3.

https://doi.org/10.1371/journal.pone.0180405.t002

Table 3. Sample size and assurance probabilities for observing criteria (i), (ii), and (iii) given = 0.025, = 0.1, (Δ , Δ ) = (3,0.45), ( , ) = (6,1), ( , ) = (0.5, 0.5), and = 0.5.

https://doi.org/10.1371/journal.pone.0180405.t003

Table 4. Sample size and assurance probabilities for observing criteria (i), (ii), and (iii) given = 0.025, = 0.1, (Δ , Δ ) = (3,0.45), ( , ) = (6,1), ( , ) = (0.5, 0.5), and = 0.7.

https://doi.org/10.1371/journal.pone.0180405.t004

In Tables 1 4 , we see the following phenomena. First of all, we found that as p 1 increases, the assurance probability of Criterion (i) increases. This is due to the fact that as p 1 increases, the observed overall results D k ’s will be increasingly dominated by the observed result from the first region, D 1 k ’s. Secondly, we have also observed that as p 1 increases, the assurance probability of Criterion (ii) increases first and then decrease later. This occurs because the observed result from regions other than the first region, ‘s, is gradually dominated by D 1 k ’s at first and is then completely dominated by D 1 k ’s later as p 1 increases. Also, the assurance probability of Criterion (iii) increases when p 1 increases, since the h i ’s decrease as p 1 increases.

Another feature we observed is that AP 1 > AP 2 in Tables 1 , 2 , 3 and 4 , given p 1 and γ k . This is due to the fact that since

Like Ikeda and Bretz [ 23 ] suggested, for Criterion (iii), it may be able to link the choice of ϕ to ( γ 1 , γ 2 ) = (0.5, 0.5) in order to ensure the same level of strictness of Criterion (i). For example, in Table 1 , setting ϕ = 0.17 in Criterion (iii) would closely ensure a similar level of strictness as Criterion (i) with p 1 = 0.4. Another point we wish to make is that the assurance probabilities of all criteria increase as ρ 12 increases. This makes intuitive sense because these two co-primary endpoints look more alike.

We recommend

  1. Shedding a tear may help
    MedicalXpress
  2. Study identifies possible biomarker for
    MedicalXpress
  3. Parkinson’s disease protein impedes nerve
    MedicalXpress
  1. Scientists show that a key
    MedicalXpress
  2. A new tool for understanding
    MedicalXpress
  3. Colonoscopy or flexible sigmoidoscopy may
    MedicalXpress
I consent to the use of Google Analytics and related cookies across the TrendMD network (widget, website, blog). Kate Spade New York Leighton Slingback Dress Pumps k6RBS4I67

Tags

Share this article

Post a comment